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diagnosis differential criticalcare hematology neurology overview shock candida candidemia coagulation demyelinating dic diseases disseminated fever fungemia histiocytosis igg4 immunecompromised immunocompromised
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Encapsulated Bacteria Cell ... jirovecii • CNS ... or Neutrophil Dysfunction ... #Causes #Hematology
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... #diagnosis #management ... #differential #causes ... #classification
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... Schistocytes, helmet cells ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... #diagnosis #management ... #differential #causes ... #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... Thyroid (Riedel's), CNS ... complement • Classification ... IGG4 #Diagnosis #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... that results in CNS ... Pleocytosis > 100 cells ... • Infectious causes ... Myelitis #diagnosis #management
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
• Endocrine Dysfunction ... marrow: Organ dysfunction ... CNS involvement: ... for endocrine dysfunctions ... Histiocytosis #Diagnosis #Management
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
organ or stem cell ... (most frequent cause ... species (commonly CNS ... include fever, organ dysfunction ... when feasible Management
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
nervous system (CNS ... Oligoclonal bands, cell ... - Symptom management ... bladder/bowel dysfunction ... diseases #neurology #CNS
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