23 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... ) Pathophysiology ... , Hb), Hepatic dysfunction ... • Familial HLH ... Lymphohistiocytosis #diagnosis #management
Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management 
Source:
Right heart dysfunction ... mechanisms and management ... right ventricular dysfunction ... of myocardial performance ... Criteria #Assessment #RVDysfunction
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... genetic immune dysfunction ... / Diagnosis: HLH ... If no response HLH ... Lymphohistiocytosis #diagnosis #management
Erectile Dysfunction: Pathogenesis

Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
Erectile Dysfunction ... Pathogenesis Erectile Dysfunction ... desired sexual performance ... Psychogenic Erectile Dysfunction ... #Pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
(Mutations in HLA ... - DR2/HLA-DR3 genes ... defects (i.e. dysfunction ... Erythematosus #SLE #Pathophysiology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (sHLH ... lymphohistiocytosis (HLH ... nervous system (CNS) dysfunction ... hypersensitivity syndromes • HLH ... Syndrome #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... cytopenias and organ dysfunction ... Persistent fever, organ dysfunction ... Pathophysiology ... Approach • Initial management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... hepatocytes → Liver dysfunction ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management ... #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... 64%) • Renal dysfunction ... 25%) • Hepatic dysfunction ... • Respiratory dysfunction ... causes #treatment #management
Vasospastic (Prinzmetal) Angina
Definition / Epidemiology:
 • Rest angina attributed to coronary artery vasospasm.
 • Patients often
Pathophysiology: ... with endothelial dysfunction ... cardiology #diagnosis #management