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diagnosis hematology management apml causes coagulation disseminated intravascular oncology syndrome
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
64%) • Renal dysfunction ... • Respiratory dysfunction ... Thromboembolism (7%) • CNS ... + Bleeding Treatment ... diagnosis #causes #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation ... Triggers: ATRA treatment ... Prednisone 5mg/kg/day vs ... 500 mg QD until normal ... severe APLS, organ dysfuxtion
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