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rheumatology management differential druginduced sle antiphospholipid apls causes comparison deficiency dermatology dil erythematosus glomerulonephritis hypercoagulable petechiae petechial physicalexam progressive rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Idiopathic • Normal ... Complement: IgA ... #differential #diagnosis ... #algorithm #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... - CRP: Usually normal ... • Immunologic Workup ... 80% - Low complement ... Erythematosus #Diagnosis
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... #Deficiency #Testing ... #Algorithm #hematology ... #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... • Immunologic Workup ... 80% - Low complement ... #diagnosis #management
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential Diagnosis ... Algorithm Pinpoint ... deficiency - Abnormal ... Autoimmune Vasculitis (lupus ... deficiency Work
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup ... Algorithm INDICATIONS ... : • Lupus Anticoagulant ... #Algorithm #diagnosis ... #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
CRP - Usually normal ... • Immunologic Workup ... 90% - Low complement ... #DIL #rheumatology ... #diagnosis #treatment
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