46 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... , and Auer rods. ... these features in ... most cases, even ... Hematology #Clinical #Smear
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
a linear red "Auer ... of crystallized granules ... most prevalent in ... BloodSmear #Blood #Smear ... #Microscopy #Auer
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
abundant cytoplasmic granules ... peripheral blood smear ... decreased secondary granules ... , Auer rods in neutrophils ... BloodSmear #Blood #Smear
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... sterile pyuria, WBC casts ... tubular proteinuria, granular ... casts/RTE; blend ... #Algorithm #nephrology
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Acellular Casts ... but can be seen in ... tubular necrosis (ATN ... Non-specific; seen in ... ) • Granular Casts
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... nonspecific; seen in ... concentrated urine Granular ... Muddy-brown" heme-granular ... in acute tubular
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
from anywhere in ... = inflammation in ... renal disease • Granular ... • “Muddy brown cast ... crystals can be found in
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... human malaria cases ... P.f. but rare in ... blood smears - ... Falciparum #Blood #Smear
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Large platelets on smear ... due to mutation in ... Large platelets on smear ... Platelet Syndrome (an ... of platelet α-granules
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
leukemias > 20% blasts in ... peripheral blood smear ... Age: 50-60 • Auer ... • Peripheral smear ... distinctive primary granules