117 results
Gustilo classification of open fractures #Diagnosis #EM #Ortho #Gustilo #Classification #Open #fractures
Gustilo classification ... Diagnosis #EM #Ortho #Gustilo
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... →Activation of CD8 ... IFN-y) → Excessive activation ... Chediak-Higashi, Griscelli, Purtilo ... Taar #HLH #Hemophagocytic
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... acquired forms of haemophagocytic ... A subset of hemophagocytic ... MAS #Macrophage #Activation
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... excessive macrophage activation ... TheIDtrivia #HLH #Hemophagocytic
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Complications Gustilo-Anderson
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... EricsMedicalLectures/ #HLH #Hemophagocytic
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation
The parasympathetic and sympathetic systems - Activation and inhibition pathways by organ system

#Sympathetic #Parasympathetic #Systems #Pathways
sympathetic systems - Activation
Fibrinolysis. 
Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
tissue plasminogen activator ... thrornbolytic drugs by activating
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
Viruses: HSV (reactivation ... Viruses: HSV (reactivation ... Viruses: CMV (reactivation ... ), VZV (reactivation ... ), CMV (reactivation