13 results
Proposed Treatment Algorithm for MAS / HLH

#MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Proposed Treatment Algorithm ... for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Management #Treatment #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... Chediak-Higashi, Griscelli, Purtilo ... • Autoimmune diseases ... Adult-onset Still disease ... #Hemophagocytic
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Hyperferritinemia Pearl: Diseases ... HLH 2. ... Still's disease ... Hyperferritinemia #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... (HLH) Definition ... age, however the disease ... / Diagnosis: HLH ... #Hemophagocytic
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
acquired forms of haemophagocytic ... A subset of hemophagocytic ... lymphohistiocytosis (HLH ... highly inflammatory disease ... hypersensitivity syndromes • HLH
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... or autoimmune disease ... for refractory disease ... #Hemophagocytic
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Differential Diagnosis Algorithm ... and Screen for HLH ... HLH syndrome 5. ... Metastatic Disease ... Differential #Diagnosis #Algorithm
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Differential Diagnosis Algorithm ... and Screen for HLH ... HLH syndrome 5 ... Metastatic Disease ... Differential #Diagnosis #Algorithm
Hypogonadism Differential Diagnosis Algorithm
 • Low testosterone, Normal or low LH, Normal or low FSH -
Differential Diagnosis Algorithm ... Normal or low LH ... testosterone, Normal LH ... Seminiferous tubule disease ... Differential #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Venoocclusive disease ... Hereditary: Wilson Disease ... PBC, PSC, IgG4, HLH ... differential #diagnosis #algorithm