11 results
Proposed Treatment Algorithm for MAS / HLH

#MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Proposed Treatment Algorithm ... for MAS / HLH ... #MAS #HLH #Hemophagocytic ... Management #Treatment #Algorithm
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Syndrome (MAS) ... A subset of hemophagocytic ... lymphohistiocytosis (HLH ... manifestation of MAS ... Plasma exchange #MAS
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... activation of macrophages ... Chediak-Higashi, Griscelli, Purtilo ... #Hemophagocytic
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... (HLH) Definition ... with excessive macrophage ... It presents as an ... #Hemophagocytic
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... Primary HLH: - ... underlying condition may ... #Hemophagocytic
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Differential Diagnosis Algorithm ... and Screen for HLH ... HLH syndrome 5. ... • Hypoplastic MDS ... Differential #Diagnosis #Algorithm
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Differential Diagnosis Algorithm ... and Screen for HLH ... HLH syndrome 5 ... • Hypoplastic MDS ... Differential #Diagnosis #Algorithm
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Exposure -> APC (macrophages ... , HLA class II) ... > lgE Abs coat mast ... binds to lgE on mast ... , eosinophils, macrophages
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Sellar / Pituitary Mass ... Differential Diagnosis Algorithm ... • TSH • LH ... Differential #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... PBC, PSC, IgG4, HLH ... synthetic function may ... differential #diagnosis #algorithm