2262 results
Gustilo classification of open fractures #Diagnosis #EM #Ortho #Gustilo #Classification #Open #fractures
Gustilo classification ... Diagnosis #EM #Ortho #Gustilo
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... • Familial HLH ... Chediak-Higashi, Griscelli, Purtilo ... XLP) Acquired HLH ... Nicolas Taar #HLH
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2. ... Hyperferritinemia #Algorithm #Differential
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup and Differential ... and Screen for HLH ... HLH syndrome 5. ... Pancytopenia #Workup #Differential
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup and Differential ... and Screen for HLH ... HLH syndrome 5 ... Pancytopenia #Workup #Differential
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... Diagnostic Criteria for HLH ... consistent with HLH ... EricsMedicalLectures/ #HLH
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... HLH or Adult Onset ... saturation to differentiate ... In adults, HLH is ... Hyperferritinemia #Differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... erythematosus • HLH ... #Pancytopenia #Differential
Differential Diagnosis for Generalized Lymphadenopathy

Viral
• HIV 
• EBV 
• CMV 
• HBV 
• Dengue 
• Rubella
Differential Diagnosis ... Amyloidosis • HLH ... Lymphadenopathy #Differential
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... genetic testing for HLH-associated ... If no response HLH ... TheIDtrivia #HLH