17 results
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
history of recurrent infections ... disease • Infectious ... community-acquired infections ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... Algorithm Extravascular ... circulation - Infections ... MAHA (TTP, DIC, HUS ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... can mimic common infections ... Treatment: • Infection ... #management #treatment ... #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Band neutrophils are ... predictive of a serious infection ... overlook severe infections ... superior indicator of infection ... neutrophil #WBC #CBC #hematology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
to a preceding infection ... • Most common infection ... jejuni • Other infections ... transplantation CLINICAL ... #management #neurology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
) - Diagnosis and ... Management Definition ... than 1500 and clinical ... hypersensitivity - Infection ... #hematology #differential
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
response preceding infection ... Can begin in arms ... Absent Reflexes: Arms ... #management #treatment ... #neurology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
, smudge cells are ... immunophenotype Clinical ... Complications: 1) Infection ... Leukemia #oncology #hematology ... #management
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... • Common clinical ... and meningismus are ... rav7ks #CNS #Infections ... #neurology #meningitis
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
proximal weakness, arms ... - Brain stem/Cranial ... myasthenia Diagnosis ... precipitated by: Drugs, infection ... #management #neurology