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management differential leukemia chronic cll hodgkins lymphocytic anemia aplastic coagulation common comparison cvid dic disorders disseminated hemeonc hypogammaglobulinemia immunodeficiency immunology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... family history - Medications ... test, ANA (e.g., SLE ... #Causes #Workup ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Metastatic cancer, Lymphoma ... • Reaction to Medications ... #Algorithm #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... translocation • Types: Classification ... • Other hematologic ... NonHodgkins #comparison #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... to large cell lymphoma ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can indicate disease ... microglobulin Treatment ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... Workup: • Full ... Treatment • Early ... #diagnosis #classification ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... specifically immune thrombocytopenia ... DDX - Other causes ... Epstein-Barr syndrome, HIV ... hypogammaglobulinemia #immunology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... - Antithyroid medications ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
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