15 results
Bleeding disorders in children

#Bleeding #Disorders #Differential #Hematology #Pediatrics #Peds
Bleeding disorders ... in children #Bleeding ... #Disorders #Differential ... #Hematology #Pediatrics ... #Peds
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... - History of bleeding ... (CVID, WAS), (neurologic ... #Differential # ... Causes #Workup #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Lymphadenopathy - Differential ... • CMV • HIV ... Leukemia - History of Bleeding ... Lymphocytes) - Monoclonal ... Algorithm #Causes #Hematology
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm
Congenital Anomaly / Disorder:
 •
Infancy (SUDI) - Differential ... Arrhythmia • Neurologic ... Sudden Infant Death Syndrome ... Algorithm #Causes #Peds ... #Pediatrics
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS) - Differential ... Diagnosis Neurologic-Centered ... capillary leak syndrome ... • Schnitzler syndrome ... #Diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Kasabach-Merritt syndrome ... • HCV, HBV Not ... #Diagnosis #hematology ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... infection, HIV infection ... Cryoglobulins: - Single monoclonal ... - Composed of monoclonal ... classification #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Cold Agglutinin Syndrome ... Mycoplasma, EBV, HIV ... younger pts) Differential ... hemolytic #anemia #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Zone Lymphoma (HCV ... et diutinum Neurologic ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Marfan syndrome, ... #Bleeding #Disorders ... #History #peds ... #pediatrics #diagnosis ... #hematology #primarycare