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differential hematology guillain acute algorithm aplastic cauda caudaequina chronic common cvid equina fatigue gap gbs globulin guillainbarre hypogammaglobulinemia immunology neuropathy
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- CMV - HCV ... - HIV • Immune ... virus (HIV) • ... #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
DDX - Other causes ... (Epstein-Barr syndrome ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Chemotherapy • Infectious ... : HIV, Hepatitis ... CIDP, Guillain-Barre ... #differential #diagnosis ... #causes #neurology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
of acute human immunodeficiency ... enzymes ↑ • Mild anemia ... DDX: • Epstein-Barr ... • Viral hepatitis ... #HIV #diagnosis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Hematologic • Anemia ... • Malignancy Infectious ... Virus • Hepatitis ... • HIV Autoimmune ... Chronic Fatigue Syndrome
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Campylobacter jejuni - HIV ... #Syndrome #diagnosis ... #management #treatment ... #neurology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... virus (HIV), and ... and cauda equina TREATMENT ... #Syndrome #diagnosis ... #management #neurology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
- Emergency Causes ... cord infarct • HIV ... cord • Guillain-Barre ... axial T1 and T2 Treatment ... #causes #neurology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... (acute HIV, HBV ... , EBV, VZV, hepatitis ... gastric tumors • Hematology ... #hematology
Syphilis - Clinical Manifestations and Treatment 1) Primary Syphilis • Direct lesion contact during sex is responsible
Albuminuria, nephrotic syndrome ... ulcerated • MSK ... individuals with HIV ... Syphilis #stages #diagnosis ... #management #Treatment
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