1821 results
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Hyperferritinemia Pearl: Diseases ... HLH 2. ... Still's disease
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Lymphohistiocytosis (HLH ... Treatment Primary HLH ... : - HLH-94 Protocol ... transplantation Secondary HLH ... cases include: HLH
Conditions Associated With Hyperferritinemia 
DDx of extreme hyperferritinemia >10,000
Not just HLH - in fact, most common
10,000 Not just HLH ... Liver disease 3. ... Transfusion - Liver Disease ... Infection-Fungai - Primary HLH ... - Secondary HLH
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... assessment+++ Primary HLH ... • Familial HLH ... XLP) Acquired HLH ... Nicolas Taar #HLH
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... genetic testing for HLH-associated ... If no response HLH ... TheIDtrivia #HLH
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Screen for HLH ... HLH syndrome 5. ... Metastatic Disease
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Screen for HLH ... HLH syndrome 5 ... Metastatic Disease
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... and Autoimmune Diseases ... erythematosus • HLH
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... highly inflammatory disease ... Adult-onset Still disease ... of underlying disease ... hypersensitivity syndromes • HLH
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... Hereditary: Wilson Disease ... PBC, PSC, IgG4, HLH ... of cholestatic disease ... Alcoholic liver disease