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diagnosis algorithm causes index lfts management obstetrics pathophysiology pregnancy aplastic calculation comparison disease elevated fatty hellp hemolysis hepatitis hospitalization icp
Calculating a Reticulocyte Index (RI) Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction Absolute Reticulocyte Count =
Calculating a Reticulocyte ... x Patient's Hct ... / Normal Hct ... Index #RI #RPI #hematology ... #diagnosis #anemia
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... NAFLD, Others • Mild ... LFTs #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production ... = (Retic %) x (Hct ... days) it takes a reticulocyte ... Production #Index #hematology ... #anemia #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Blood Smear ↑ abnormal ... RBCs - Reticulocyte ... #Diagnosis #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
• Histology: Normal-mild ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential ... diagnosis #icp #HELLP #AFLP
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... NAFLD • Others Mild ... Others #LFTs #Hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Pregnancy #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
syndrome (MDS) (normal ... megakaryocytes and a normal ... WBC • ↓ PLT • Reticulocyte ... • Allogeneic HSCT ... #oncology #hematology
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
Why does the Hgb/Hct ... -6% drop in Hg/Hct ... 30 min and Hg/Hct ... concentrating Hg/Hct ... Decrease of Hg/Hct
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