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diagnosis algorithm anemia oncology pathophysiology pulmonary polycythemia reactions workup aflp aplastic arterial aspergillus betadglucan biomarkers bloodproduct boop bronchiectasis calculation cancer
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
Blood Product Components ... Hct 35%. 450mL blood ... red cells have a Hct ... Hct 60% Platelet ... Contents #Volume #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Dyspnea - Differential ... • Parenchyma: ILD ... Water - Pus - Blood ... Transverse myelitis • Hematology ... #dyspnea #sob #differential
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
- Polycythemia Differential ... Hb > 16.5 g/dL/HCT ... : Hb > 16 g/dL/HCT ... Polycythemia - Acquired Causes ... Diagnosis #Algorithm #hematology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... products - ... and allogeneic HSCT ... BAL GM does not differentiate ... 100d following HSCT
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
acid metabolism products ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Hb>16.5 g/dL, Hct ... Hb>16.0 g/dL, Hct ... Better call hematology ... Algorithm #workup #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... the peripheral blood ... > 3: • Acute blood ... Production #Index #hematology ... #anemia #differential
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... May have drop in Hct ... Blood products contain ... #diagnosis #management ... #hematology #reactions
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... decrease in most cases ... of Peripheral blood ... WBC count and differential ... Diagnosis #Workup #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... cytokines (TNFa,lL1, IL6 ... Drugs, Unknown cause ... PTLD), allogeneic HSCT ... Lymphohistiocytosis #diagnosis #management
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