22 results
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Diagnosis and Management ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... hepatitis C virus ... DAAs #Antivirals #table ... infectiousdisease #hepatology ... #Management #Pharmacology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
NASH, Chronic ... viral hepatitis: ... injury: > 3 • Chronic ... #injury #hepatitis ... diagnosis #algorithm #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Differential Diagnosis Chronic ... liver disease ( ... cirrhosis or chronic ... hepatitis) - 80% ... , Renal Disease,
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... (DILI) Viral Hepatitis ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... D/E, EBV, CMV, HSV ... HELLP, Celiac disease ... Transaminitis #LFTs ... #hepatitis
Hepatitis B Disease Progression Timeline
 • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... disease (<5% of ... develop Liver Cancer ... developing cirrhosis #HepatitisB ... Timeline #Prognosis #hepatology