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diagnosis hepatology differential algorithm rheumatology hepatitis injury transaminitis gastroenterology treatment blood causes comparison dermatology druginduced hbv lupus product reactions sle
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... Metabolic: Wilson Disease ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Diagnosis #causes #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Iatrogenic: DILI ... • NASH, Chronic ... viral hepatitis: ... injury: > 3 • Chronic ... diagnosis #algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Diagnosis and Management ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Injury (DILI) ... Viral Hepatitis ... #Cirrhosis #Hepatology
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... hepatitis C virus ... DAAs #Antivirals #table ... infectiousdisease #hepatology ... #Management #Pharmacology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... transaminitis #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
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