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diagnosis hepatology algorithm differential injury rheumatology druginduced gastroenterology hepatitis product reactions aclf acute alcoholic arthritis chemistry cirrhosis classification common comparison
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Iatrogenic: DILI ... • NASH, Chronic ... injury: > 3 • Chronic ... intestines, white blood ... diagnosis #algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Injury (DILI) ... Viral Hepatitis ... #Cirrhosis #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... intestines, White blood ... transaminitis #LFTs
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... • Evolution: Chronic ... disease Dr. ... sle #comparison #table ... #rheumatology #
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... with chest x-ray, blood ... - Concomitant diseases ... HCV, DILI, HCC, ... #hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... • Liver diseases ... and hepatitis ... Malignancies • Chronic ... hypogammaglobulinemia #immunology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... mucositis - Rash ... pulses, bruis, or blood ... Large Vessel: Blood ... Tests: • CBC • LFT
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Polyarthritis: • Blood ... Screening Tests for Chronic ... : • Complete blood ... profile, including liver ... function tests (LFTs
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