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diagnosis hepatology differential algorithm injury transaminitis rheumatology treatment causes druginduced gastroenterology hbv aclf acute adultonset aih alcoholic antivirals arthritis ascites
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... hepatitis C virus ... DAAs #Antivirals #table ... #HepC #HepatitisC ... #Management #Pharmacology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... Metabolic: Wilson Disease ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
- Acute Viral Hepatitis ... , Toxic Hepatitis ... 5-10x normal - Chronic ... hepatitis, Skeletal ... #LFTs #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... • NASH, Chronic ... viral hepatitis: ... injury: > 3 • Chronic ... #injury #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Check Acute viral hepatitis ... Check Acute viral hepatitis ... • NASH, Chronic ... viral hepatitis:
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