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hepatology diagnosis algorithm differential hbv hepatitis hepbv transaminitis druginduced gastroenterology lupus rheumatology sle aclf acute aih alcoholic antivirals autoimmune chemistry
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... non-essential drug/HDS treatments ... e.g. ascites), Chronic ... hepatitis fibrosis ... #Liver #Injury
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... presentation • Chronic ... - ongoing ↑ LFTs ... gastroenterology #hepatology
Hepatitis B Phases and Treatment Phase 1 - HBeAg+ Chronic Infection Phase 2 - HBeAg+ Chronic Hepatitis Phase 3
Hepatitis B Phases ... + Chronic Hepatitis ... - Chronic Hepatitis ... #HBV #HepBV #Phases ... #Treatment #Management
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... between the above phases ... HAV immunity; Liver ... Chronic Hepatitis ... #Treatment #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... • Iatrogenic: DILI ... , Chronic viral ... : > 3 • Chronic ... #injury #hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... Viral Hepatitis ... #Cirrhosis #Hepatology
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... DAAs #Antivirals #table ... #treatment #hcv ... infectiousdisease #hepatology ... #Management #Pharmacology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 • NASH ... , Chronic viral ... : > 3 • Chronic ... transaminitis #LFTs
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