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diagnosis differential management hematology syndrome barre eschar guillain photo spinalcord algorithm anemia aplastic brain cauda caudaequina common cryofibrinogenemia crypto cryptococcal
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... lesion: Clinical ... Cord Causes: 1 ... Viral: VZV, HSV, ... HIV, CMV, HTLV
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
cord - Spinal Cord ... result in permanent neurologic ... Causes of spinal ... Infarction - Infection ... syphilis, and HIV
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
disorder of the spinal ... Transverse Myelitis - Clinical ... causes need to ... simplex virus, HIV ... diagnosis #management #neurology
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
cord and nerve ... roots Spinal Cord ... (IRIS): • In HIV ... neurological symptoms • Caused ... and not direct infection
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
- Emergency Causes ... cord infarct ... • HIV related myelopathy ... infection/abscess ... #neurology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Avg age of DX ... to 8 years Clinical ... DDX - Other causes ... Epstein-Barr syndrome, HIV ... hypogammaglobulinemia #immunology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - CMV - HCV ... - HIV • Immune ... and thymoma DDX ... immunodeficiency virus (HIV
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Incidence: 1 to 2 cases ... immunodeficiency virus (HIV ... transplantation CLINICAL ... specific therapy, the clinician ... diagnosis #management #neurology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Malignancy • Infections ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... Cryofibrinogenemia DDX ... • TTP, HUS and HIT
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
response preceding infection ... Campylobacter jejuni - HIV ... Guillain-Barre Clinical ... of intrathecal spinal ... management #treatment #neurology
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