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Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
Non-HCV infectious ... cryoglobulinemia vasculitis ... Clinical manifestations ... frequently related to HBV ... #Rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... : HCV infection, ... HBV infection, ... HIV infection ... classification #rheumatology
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
indicates an acute HBV ... when fighting a HBV ... indicates a chronic HBV ... infected with HBV ... commonly run in the clinical
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... - Due to Viral infection ... Clinical Presentation ... Mycoplasma, EBV, HIV ... hemolytic #anemia #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
to exclude are infections ... CTD) • ANCA (Dx ... Cryoglobulins • HIV ... • HBV HCV • ... differential #diagnosis #rheumatology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
of the spinal cord ... • Infectious: ... Myeloma/amyloid • Infectious ... parainfluenza, Coxsackie, HIV ... Differential #Diagnosis #neurology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
neurological lesion: Clinical ... Infections: - ... Viral: VZV, HSV, ... HIV, CMV, HTLV ... disorders #diagnosis #neurology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Avg age of DX ... to 8 years Clinical ... DDX - Other causes ... Epstein-Barr syndrome, HIV ... hypogammaglobulinemia #immunology #hematology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Direct microbial infection ... Transverse Myelitis - Clinical ... simplex virus, HIV ... - Sjogren - Vasculitis ... diagnosis #management #neurology
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... (IRIS): • In HIV ... Meningitis • Include: vasculitis ... and not direct infection