Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic antinuclear ana patterns antibodies disease autoimmune arthritis anca treatment table phenotypes

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Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... Positive ANA ≠ Autoimmune ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... #Antibodies #ANA ... #patterns #rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... Association with disease ... searched for when ANA ... with auto-immune diseases ... #table #ANA

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

findings (ANA, ... Decade Skin Disease ... tissue disease ... rheumatologic diseases ... Serositis Labs: • ANA

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

: - ANA > ... of autoantibodies ... : - ANA > ... Evolution: Chronic disease ... #rheumatology #

Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain

• Anti-NXP2 (ANA ... Interstitial lung disease ... Interstitial lung disease ... or head drop • ANA ... skeletal muscle disease

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