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differential vasculitis ana antinuclear associations classification lupus autoimmune comparison cryoglobulinemia cryoglobulins erythematosus laboratory management myopathy testing types vasculitides
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
with different rheumatic ... Rheumatic Diseases ... • Rheumatic Diseases ... Syndrome, Myositis ... #rheumatology #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA ... others (RNP, aPL antibodies ... ribonucleoprotein) • RA: Rheumatoid ... • Scleroderma (Systemic ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... hepatitis Anti-CCP, Rheumatoid ... (TTG) - Celiac disease ... #diagnosis #table ... antibodies
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic ... Diseases: • Homogeneous ... connective tissue disease ... #rheumatology #diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... connective-tissue disease ... #Disease #Rheumatoid ... #workup #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... : Systemic rheumatic ... diseases, such ... atherosclerotic disease ... ) pattern: antibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... vasculitis, rheumatoid ... Still disease, ... diseases (i.e.
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... respectively, having rheumatoid ... Elevated serum rheumatoid ... cytoplasmic antibody ... ), rheumatoid arthritis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... months to years) Systemic ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... diseases, such ... disease, drug reactions ... most important diseases ... (GRANULOMATOUS DISEASE
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