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diagnosis hematology lupus management cll erythematosus leukemia oncology sle vasculitis antinuclear associations classification comparison cvid druginduced hemeonc hypogammaglobulinemia immunodeficiency immunology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... ANA - Non-specific ... ; common in SLE, ... antibodies
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Overview: • Most common ... cytometry → >500/uL ... chemotherapy for low-risk disease ... 3) Monoclonal antibodies
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... rendering the immune system ... Epidemiology: • Most common ... cells can indicate disease ... #diagnosis #workup
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
lung disease ... Gastrointestinal inflammatory disease ... Granulomatous disease ... • Liver diseases ... interstitial lung disease
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... tissue disease ... rheumatologic diseases ... ) • Kikuchi disease ... Kidney disease common
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #table #ANA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
of autoantibodies ... • Evolution: Chronic ... disease Dr. ... sle #comparison #table ... #rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Interstitial lung disease ... Interstitial lung disease ... Interstitial lung disease ... skeletal muscle disease ... myocarditis Other Diseases
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
rheumatic diseases ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... HBV Kawasaki Disease
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