11 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... tissue disease ... Syndrome (SS), ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Syndrome (SS), ... , Sjögren Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Diagnosis and Lupus ... #Diagnosis #autoantibodies ... #signs #symptoms ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... overlap syndromes ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus Erythematosus ... : Chronic disease ... #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... lupus erythematosus ... ) pattern: antibodies ... #diagnosis #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... • Mikulicz syndrome ... #Sjogrens #Syndrome ... #Rheumatology # ... Diagnosis #Management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... lupus erythematosus ... (SLE) - Antinuclear ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Antisynthetase syndrome ... lymphoma Overlap Syndrome ... ANTI-SYNTHETASE SYNDROME ... paraneoplastic syndrome ... #Myopathy #rheumatology