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diagnosis antinuclear antibodies management pulmonary renal antineutrophil aortitis cryoglobulins hematology inflammatory monoclonal nephrology neurology oncology paraproteinemias prs size sle table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... lupus erythematosus ... cases • Sjögren syndrome ... connective tissue disease ... #diseases
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
• +ANA can be seen ... : The ANA patterns ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... • Systemic lupus ... polychondritis • Behcet disease ... spectrum disorder • ANCA-associated
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #patterns #rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
small vessels - ANCA-associated ... Churg-Strauss syndrome ... lupus erythematosus ... - Schnitzler syndrome ... - Sjögren syndrome
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal Syndrome ... Pulmonary Renal Syndromes ... disease, Cryoglobulinemia ... lupus erythematosus ... Goodpasture's Disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... lupus erythematosus ... LFT • ESR • ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... lupus erythematosus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... syndrome in 80% ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... lupus erythematosus
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