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antibodies antinuclear hematology management syndromes antibody antineutrophil aortitis bee causes complement cryoglobulinemia cryoglobulins high hyperkalemia hypocomplementemia low mnemonic monoclonal myopathy
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... : The ANA patterns ... lupus erythematosus ... #patterns #rheumatology ... #diagnosis #differential
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic Diseases ... connective tissue disease ... #patterns #rheumatology ... #diagnosis #differential
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... arteritis - Inflammatory ... small vessels - ANCA-associated ... lupus erythematosus ... #Diagnosis #Rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
less common diseases ... Vogt-Koyanagi-Harada (VKH) disease ... • Systemic lupus ... polychondritis • Behcet disease ... spectrum disorder • ANCA-associated
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... Jcortesizaguirr #ANA ... diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... Diagnosis: Systemic ... rheumatic diseases ... lupus erythematosus ... differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... rheumatologic diseases ... antibodies • (-) ANA ... #Diagnosis #Rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... lupus erythematosus ... #Diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... antiphospholipid syndrome ... Lupus Erythematosus ... #differential #
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 ... and Autoimmune ... Diseases: • Systemic ... lupus erythematosus ... #Diagnosis #Hematology
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