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differential antinuclear classification management patterns sle table vasculitis comparison cryoglobulinemia inflammatory pathophysiology primary rheumatoid signs tafro testing thrombocytopenia types vasculitides
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Rheumatic Diseases ... Syndrome (SS), ... • Rheumatic Diseases ... Syndrome, Myositis ... #rheumatology #diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Diseases: • Homogeneous ... connective tissue disease ... Syndrome (SS), ... #rheumatology #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
s Syndrome: Pathogenesis ... diseases • In ... , the syndrome may ... diseases like rheumatoid ... or systemic lupus
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... • Sjögren syndrome ... • Systemic lupus ... #Syndromes #neurology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
syndrome, and mixed ... rheumatologic diseases ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... syndrome - type ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... arthritis, Sjögren's
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... : Systemic rheumatic ... as systemic lupus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
, Arthritis, myalgia ... : - ANA > ... Lupus Erythematosus ... : - ANA > ... Evolution: Chronic disease
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... Association with disease ... SLE-SSc-AlM overlap syndromes ... with auto-immune diseases ... #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... lupus erythematosus ... #Disease #Rheumatoid ... #workup #diagnosis
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