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differential classification antinuclear aortitis associations cryofibrinogenemia cryoglobulins hematology inflammatory management nephrology patterns pulmonary renal sle table tafro testing thrombocytopenia types
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Rheumatic Diseases ... SLE), Sjogren's Syndrome ... • Rheumatic Diseases ... Syndrome, Myositis ... #rheumatology #diagnosis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
, Cogan's Syndrome ... Nodosa (PAN), ANCA ... associated vasculitis ... (rare) • Rheumatic ... Systemic lupus
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... hepatitis Anti-CCP, Rheumatoid ... La) - Sjogren's syndrome ... c-ANCA - Vasculitis ... - Vasculitis, e.g
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
vasculitis, Behcet ... disease, Cryoglobulinemia ... lupus erythematosus ... , Rheumatoid arthritis ... , anti-GBM ab, ANA
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... • Systemic lupus ... vasculitides • ... #Syndromes #neurology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... : Systemic rheumatic ... as systemic lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... rheumatologic diseases ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... Elevated serum rheumatoid ... lupus erythematosus ... (SLE), rheumatoid ... syndrome) #Cryoglobulinemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... diseases, such ... Mucocutaneous lymph node syndrome ... • Behcet syndrome ... • Cogan syndrome
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... lupus erythematosus ... #Disease #Rheumatoid ... #workup #diagnosis
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