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differential antinuclear classification antibody antineutrophil arthritis associations cryofibrinogenemia cryoglobulins inflammatory management monoclonal oncology paraproteinemias patterns rheumatoid sle table tafro testing
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... La) - Sjogren's syndrome ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Rheumatic Diseases ... SLE), Sjogren's Syndrome ... • Rheumatic Diseases ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... less common diseases ... • Systemic lupus ... vasculitides • ... #Syndromes #neurology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... cases • Sjögren syndrome ... Vasculitis: • ... Renal-limited vasculitis ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... • Cogan Syndrome ... : Systemic rheumatic ... as systemic lupus ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... rheumatologic diseases ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
syndrome in 80% ... diseases: - 10% ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... Mucocutaneous lymph node syndrome ... • Behcet syndrome ... • Cogan syndrome ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... lupus erythematosus ... #Disease #Rheumatoid ... #workup #diagnosis ... #testing #Rheumatology
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