18 results
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... constitutional symptoms • Treatment ... • Evolution: ... life-threatening • Treatment ... management of SLE • Evolution
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... of SLE versus DIL ... life-threatening • Treatment ... management of SLE • Evolution
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... renal histological evaluation ... BaillouChloe #Lupus ... Nephritis #Management #treatment
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... : -10% of all lupus ... constitutional symptoms • Treatment ... • Evolution: ... #diagnosis #treatment
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Toxins, Cytokines (IL ... -1, TNF-a1pha, IL ... production • Treatment ... Serotonin syndrome • Treatment ... Cool damp sponge bath
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor and lupus ... Willebrand syndrome • Lupus ... administration, evaluation ... The appropriate evaluations ... disease • Acute DIC
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
hemoglobin of 6.8 g/dL ... hospitalization and treatment ... #Clinical #Path
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
cytokines, such as IL ... -1 and IL-6, leading ... disease • Systemic lupus ... SJIA], systemic lupus ... Treatment: • Corticosteroids
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Unknown cause Treatment ... inhibitors under evaluation ... diagnosis #management #treatment
Shock - Diagnosis and Management Summary
 • Hypotension: SBP<90, SBP drop >40, MAP<65 (Normotension, HTN possible
IV's, Consider IL ... abnormalities - Cath ... #criticalcare #treatment