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diagnosis clinical differential management algorithm rheumatology nephrology rhabdomyolysis pathophysiology treatment workup causes comparison microscopy msk myopathy neurology pathology signs symptoms
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Creatine kinase (CK ... ) hallmark of rhabdomyolysis ... Defined based on CK ... • Half-life of CK ... and cefdinir #CK
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... creatine kinase (CK ... are the hallmark ... CK functions as
Here are the morphological hallmarks of Rhabdomyosarcoma. - Broken arrow sign - tad-pole rhabdomyoblasts
morphological hallmarks ... Rhabdomyosarcoma #Hallmarks
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
weakness • Elevated CK ... rash • Elevated CK ... Elevated ESR, Normal CK ... mildly elevated CK ... Myositis: elevated CK
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Tests #Locations #AlkPhos
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
eosinophilic hof (Hallmark ... but still has hallmark ... largecell #lymphoma #ALKPos
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK
Algorithm for evaluation of elevated serum alkaline phosphatase. #Algorithm #elevated #alkaline #phosphatase #AlkPhos #Elevation #Diagnosis #workup
#phosphatase #AlkPhos
Usmle step 2 ck Pulmonary diseases (High yield points) #usmle #algorithm
Usmle step 2 ck
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