37 results
CASTLEMAN DISEASE
Disorder of the immune system with excessive production of IL-6

Castleman’s disease is a rare, heterogeneous
CASTLEMAN DISEASE ... production of IL-6 Castleman ... • Unicentric Castleman ... • Multicentric Castleman ... 6 levels are a hallmark
Here are the morphological hallmarks of Rhabdomyosarcoma.

 - Broken arrow sign 

 - tad-pole rhabdomyoblasts
morphological hallmarks ... Rhabdomyosarcoma #Hallmarks
Pathology - Castleman disease. 

Mediastinal mass in a younger woman.

Histologic Features of Castleman disease, hyaline vascular
Pathology - Castleman ... Histologic Features of Castleman ... @mjcascio #Castleman
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... associated with Castleman's ... faheema_hasan #Castlemans
Hallmark ECG features of Ventricular Tachycardia (VT)
AV indicates atrioventricular; LAD, left axis deviation; LBBB, left bundle
Hallmark ECG features
Lymphadenopathy - Differential Diagnosis Algorithm
Localized: 
 • Cervical: EBV, CMV, HIV, Toxo, TB, Lymphoma, Head /
Miscellaneous: Castleman's
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Hypothalamic dysfunction, Castleman
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Creatine kinase (CK) hallmark
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy
Malignancies
 - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms
Infections
 -
node hyperplasia (Castleman
Anaplastic large cell lymphoma, ALK+
Clinical
 • First 3 decades of life, M>F
 • Often nodal +
eosinophilic hof (Hallmark ... but still has hallmark