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diagnosis hematology causes workup @dharsaty approach classification dm2 eas elevation evaluation false fructosamine glycatedproteins hemoglobina1c hgba1c laboratory normocytic perioperative preop
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Reduction == Increase ... blood loss • Hemolytic ... anemia • Splenomegaly ... #Increase #Decrease ... Diagnosis #DM2 #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Diagnosis Algorithm ... Decreased WBCs ... - Decreased/NormaI ... #Differential #
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Decreased RBC ... Classification #Approach #Differential ... #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... without platelet decrease ... #Anemia #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... schistocytes, nucleated RBCs ... anemia Indirect ... WBC count and differential
Hemoglobin A1c (glycated hemoglobin) reflects the average blood glucose concentration over the course of the RBC
plasma glucose increases ... correlated with 35-76% decrease ... span, such as hemolytic ... anemia or blood ... , increased RBC
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
delaying the surgery increase ... event, follow ACC algorithm ... Cataract Plan for Meds ... are needed: • HgbA1c ... or death (CARP, DECREASE
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