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hematology differential monoclonal acute cancer classification clinical gammopathy gap globulin injury kidney leukostasis lysis management mds myelodysplasia myelodysplastic nephrology paraproteinemias
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Kidney Injury (AKI ... disease (LCDD) • Heavy ... significance (MGRS ... #Cancer #Oncology ... #Differential #Diagnosis
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... - Differential Diagnosis ... capillary leak syndrome ... light chain vs. heavy ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • CLL & MBL • Heavy ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... infiltrates - 80% have ... fever - ACS, AKI ... : • Pathophysiology ... #TLS #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Exposure to heavy ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... changes (POEMS syndrome ... Determine heavy/ ... #differential #diagnosis
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