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diagnosis differential chronic hemeonc lymphocytic monoclonal defects emergencies gammopathy gap globulin inherited management mds myelodysplasia myelodysplastic oncologic paraproteinemias platelet protein
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... • Richter’s Syndrome ... syndrome • Smoldering ... #diagnosis #workup ... #oncology #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... Lymphoma (HCV) • CLL ... & MBL • Heavy ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
disorder characterized ... immunoglobulin heavy-chain ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... in adults • Disorder ... →several RCTs have ... uw_IMresidency #CLL ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Cell Leukemia ... #diagnosis #hematology ... #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Rare Disorder: ... general feeling of ill ... , breast CA - Hematologic ... #diagnosis #dermatology ... #oncology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
MYH9-Related Disorder ... structure and cell ... non-muscle myosin heavy ... Platelet #Defects #comparison ... differential #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... patients will have ... ): - Hematologic ... Usually myeloid leukemias
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