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diagnosis hepatology pathophysiology clinical pathophys schistocytes acanthocytes acetaminophen alkphos antimda5 antimda5dm apap astalt autoimmune bilirubin bite blister blood bloodsmear burrcells
Several artifacts can cause significant and potentially misleading alterations to measured RBC parameters: 1. Old samples
BurrCells #Bite #Keratocyte ... #Blister #HelmetCells
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... from albumin upon hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte
Pathology - Hepatocyte Pigments Lipofuschin (H&E) Alpha-I-antitrypsin globules (PAS-D) Mallory's hyaline / Mallory Denk Bodies Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte
Schistocytes can assume a shape resembling natural or man-made objects such as arrowheads, fish, collar buttons,
Smear #Helmet #HelmetCells
Pemphigus vulgaris (PV) is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. It
autoantibodies against keratinocyte ... enzymes that mediate keratinocyte
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
the extent of hepatocyte
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
epithelial and hepatocyte
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
Within the hepatocyte
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
steatosis and hepatocyte
Keratoconus: Pathogenesis and Clinical Findings Genetics • Family history of keratoconus • Ehlers-Danlos syndrome • Down, Turner,
• Decr Stromal keratocytes
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