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diagnosis hematology differential causes algorithm bruising disorders prolonged thrombocytopenia abnormal activation aptt blanching bruise chemistry dic disseminated ecchymosis hematomas hemostasis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
(INR) - Bleeding ... (INR) - No Bleeding ... #INR #Differential ... Algorithm #Causes #Hematology ... #coagulation #disorders
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Proteins - Acquired ... #Bleeding #Bruising ... #Differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Subcutaneous dissecting hematoma ... Fibrinogen: ↓ • PT ... causes #treatment #management ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... intravascular coagulation ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Hematoma is a collection ... are typical of coagulation ... to be normal, PT ... Measurement of coagulation ... VWF:RCo/VWF:Ag (differentiate
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Acquired deficiency ... Congenital intrinsic coagulation ... intravascular coagulation ... Causes #diagnosis #differential ... #hematology #coagulation
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... - History of bleeding ... epistaxis, gingival bleeding ... selected cases: INR/PT ... evaluation: not required
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... factors: PT/INR ... RBC (hemolysis, bleeding ... , hematoma) • ... chemistry #diagnosis #differential
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... purpura to mucosal bleeding ... Hypofibrinogenemia • ↑ PT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
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