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algorithm hematology lfts management obstetrics arterial biliary chemistry cholangitis cirrhosis comparison dic disease disseminated embolism fatty hellp icp injury interpretation
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Hepatitis, Preeclampsia ... Pregnancy #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic infarcts, Hematomas ... of Pregnancy (AFLP ... #hepatitis #comparison ... #differential # ... diagnosis #icp #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... hemolysis, bleeding, hematoma ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... - AFLP, HELLP ... • Alcoholic hepatitis ... #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Vascular Causes ... melanoma, myeloma • Pregnancy ... hemolysis, bleeding, hematoma ... #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Subcutaneous dissecting hematoma ... DIC • Severe Liver ... Treat primary cause ... #diagnosis #causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... Viral hepatitis, ... cholestasis of pregnancy ... #workup #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Intravenous Drug Use • Pregnancy ... Syndrome, Ischemic Liver ... intravascular coagulation ... and other causes ... #hematology #differential
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