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diagnosis rheumatology differential lupus signs sle management antinuclear arthritis autoantibodies classification disease gca giantcell laboratory macrophage mas mimickers patterns rheumatic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... 1, SCL-70, RNP antibodies ... Chronic B-cell activation
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... lupus erythematosus ... #rheumatology #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... ) Blood (75%): Anemia ... #erythematosus ... #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... lupus erythematosus ... Symptoms (Sx) in ... LFT • ESR • ANA ... ) pattern: antibodies
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... - Hemolytic anemia ... SLE-Related Auto-Antibodies ... : - ANA 95-100%
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... Symptoms (SX) in ... ischemia • Skin: Erythematous ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... lupus erythematosus ... lupus erythematosus ... with leukopenia, anemia ... Diagnosis #Management #Hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
inflammatory vasculitis ... differential diagnosis = vasculitis ... complaints- anemia ... absence of visual symptoms ... Temporal #Signs #Symptoms
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... lupus erythematosus ... antibodies, which ... the presence of anemia
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