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diagnosis rheumatology differential classification lupus signs sle allergy disease hypersensitivity management reactions syndrome table types agglutinin antinuclear arthritis autoantibodies autoimmune
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... (NPSLE): • May ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... Chronic B-cell activation
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... lupus erythematosus ... #rheumatology #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... ) Blood (75%): Anemia ... #erythematosus ... #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... erythematosus, atherosclerotic ... Symptoms (Sx) in ... LFT • ESR • ANA ... ) pattern: antibodies
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... - Hemolytic anemia ... SLE-Related Auto-Antibodies ... autoantibodies #signs #symptoms
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... juvenile idiopathic arthritis ... lupus erythematosus ... lupus erythematosus ... with leukopenia, anemia
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Local and systemic ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... erythematosus
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... Symptoms (SX) in ... ischemia • Skin: Erythematous ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... Cryoglobulins (Vasculitic ... of anemia include ... #hematology #diagnosis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
inflammatory vasculitis ... complaints- anemia ... pain that worsens as ... absence of visual symptoms ... Temporal #Signs #Symptoms
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