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differential algorithm management causes clinical cardiology radiology pulmonary pocus table signs comparison symptoms neurology classification pathophysiology peds hematology nephrology workup
Thalassemias on Hemoglobin Electrophoresis Beta-Thalassemia: • Major • Intermediate • Trait Alpha Thalassemia: • Trait-1 (α α/ α-)
Thalassemias on Hemoglobin ... or (α α/ --) • Hemoglobin ... H (α -/ --) • Hemoglobin ... Barts(- -/ --) Hemoglobin ... interpretation #diagnosis
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes: Conditions with Abnormal RBCs: •
The differential diagnosis ... mean corpuscular hemoglobin ... Sickle cells • Hemoglobin ... Hemolysis (i.e., free hemoglobin ... #Differential #Diagnosis
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
drugs, Unstable hemoglobin ... Post-splenectomy • Hemoglobin ... H Inclusion: Hemoglobin ... Inclusions #Bodies #diagnosis
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
proportion to the ↓ in hemoglobin ... • Hemoglobin ... available for Hemoglobin ... available for hemoglobin ... #ferritin #Fe #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
SS disease, Hemoglobin ... Hemoglobin C Crystals ... : Hemoglobin C disease ... , Hemoglobin SC ... #differential #diagnosis
Thalassemia - Electrophoresis - Comparison Table In this disorder it is the defective production of hemoglobin that
production of hemoglobin ... alpha-thalassemia and Hemoglobin ... Electrophoresis #Diagnosis
Red Blood Cell Morphology Atlas Size variation, Hemoglobin distribution, Hypochromia, Shape variation, Inclusions, Red
Size variation, Hemoglobin ... distribution #Diagnosis
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... Haptoglobin, LDH, Urine hemoglobin ... Haptoglobin • ↑ Urine hemoglobin ... #Differential #Diagnosis
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
- Differential Diagnosis ... Internal - Hemoglobin ... #Differential #Diagnosis
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
hemosiderin Urine hemoglobin ... Testing #workup #diagnosis
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