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Thalassemias on Hemoglobin Electrophoresis Beta-Thalassemia: • Major • Intermediate • Trait Alpha Thalassemia: • Trait-1 (α α/ α-)
Thalassemias on Hemoglobin ... or (α α/ --) • Hemoglobin ... H (α -/ --) • Hemoglobin ... Barts(- -/ --) Hemoglobin ... interpretation #diagnosis #hematology
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
drugs, Unstable hemoglobin ... Post-splenectomy • Hemoglobin ... H Inclusion: Hemoglobin ... Bodies #diagnosis #hematology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
proportion to the ↓ in hemoglobin ... • Hemoglobin ... available for Hemoglobin ... available for hemoglobin ... Fe #diagnosis #hematology
Thalassemia - Electrophoresis - Comparison Table In this disorder it is the defective production of hemoglobin that
production of hemoglobin ... alpha-thalassemia and Hemoglobin ... Comparison #Table #Hematology
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
hemosiderin Urine hemoglobin ... workup #diagnosis #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Internal - Hemoglobin ... Diagnosis #Causes #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
SS disease, Hemoglobin ... Hemoglobin C Crystals ... : Hemoglobin C disease ... , Hemoglobin SC ... differential #diagnosis #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Haptoglobin, LDH, Urine hemoglobin ... Haptoglobin • ↑ Urine hemoglobin ... Management #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
deficiency, Unstable hemoglobin ... metabolism defects, Hemoglobin ... Algorithm #workup #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Pyruvate kinase - Hemoglobin ... Differential #Diagnosis #hematology
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