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diagnosis autoimmune erythematosus hemolytic management sle systemic vasculitis aids antibody arteritis classification comparison extravascular gca giantcell hematology hemolysis hiv infections
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
reticulocytes • Hemolysis ... LDH • Anti-RBC autoantibodies ... • Blood smear: Differential ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... Erythematosus #Diagnosis #autoantibodies ... #signs #symptoms ... #mimickers #differential ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology ... #anemia
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
associated with rheumatologic ... presentation of systemic lupus ... life-threatening causes ... #Pericarditis #Symptoms ... #Signs #Presentation
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 SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... : • Symptoms limited
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... < 30 years - Aorta ... Presentation - Systemic Symptoms ... purpura: strong sign ... #diagnosis #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
those coming off aorta ... systemic sx + signs ... very remarkable w/differential ... systemic complaints- anemia ... them, but urgent rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... < 30 years • Aorta ... Arteritis): • Aorta ... tract, and often causes ... #Diagnosis #Rheumatology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Infections in HIV - Differential ... Hemoptysis (occasionally ... • CT: Halo sign ... Constitutional symptoms ... ), anemia, arthralgia
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... ) • Shawl sign ... Mechanic's hands Autoantibodies ... statins - probably caused ... #differential #
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