33 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... smear, HIV/HCV testing ... changes), high MCV anemia ... #Differential #Diagnosis ... #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... reticulocytes • Hemolysis ... 2) LOOK FOR a cause ... → Systematic screening ... #treatment #rheumatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... for secondary causes ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... lymphoproliferative disorders ... Extravascular #Causes ... #hematology #anemia
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Endocarditis, Aortic ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
anemia • Cold ... Positive Coombs testing ... • Compensated hemolysis ... intravascular hemolysis ... #hematology #diagnosis
Causes of Bradykinetic Movement Disorders - Differential Diagnosis Algorithm
Parkinson's Disease (TRAP):
• Resting Tremor
• Cogwheel Rigidity
• Akinesia/Bradykinesia
•
Causes of Bradykinetic ... Movement Disorders ... Disease (TRAP): • Resting ... backwards Multiple System ... • Cerebellar signs
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider RBC membrane disorder ... elliptocytosis, autoimmune hemolysis ... Algorithm #workup #hematology ... #testing