26 results
differential rheumatology symptoms workup management algorithm causes sclerosis erythematosus hemolytic lupus oncology sle syndrome vasculitis agglutinin als amyotrophic anorexianervosa arteritis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... : • Systemic lupus ... Antibody-mediated hemolysis ... #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Endocarditis, Aortic ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... interstitial lung disease ... #diagnosis #signs ... #symptoms #testing
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... elliptocytosis, autoimmune hemolysis ... Algorithm #workup #hematology ... #testing
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Fever, Hematuria, Hemoptysis ... Differential Diagnosis ... Immune Complex: Systemic ... testing: anti-ANCA ... #nephrology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Positive Coombs testing ... • Compensated hemolysis ... intravascular hemolysis ... #hematology #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Causes of Bradykinetic Movement Disorders - Differential Diagnosis Algorithm Parkinson's Disease (TRAP): • Resting Tremor • Cogwheel Rigidity • Akinesia/Bradykinesia •
Algorithm Parkinson's Disease ... (TRAP): • Resting ... backwards Multiple System ... • Cerebellar signs ... MovementDisorders #Neurology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... smear, HIV/HCV testing ... PT, aPTT(liver disease ... (CVID, WAS), (neurologic ... changes), high MCV anemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... < 30 years • Aorta ... Arteritis): • Aorta ... affects the skin, neurologic ... #Rheumatology
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