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diagnosis hepatology differential clinical ultrasound pocus management algorithm causes radiology abscess hematology pathophysiology cirrhosis comparison lfts table gastroenterology laboratory obstetrics
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
: <5 mg/dL • Hepatic ... imaging: Hepatic ... of Pregnancy (AFLP ... if severe • Hepatic ... diagnosis #icp #HELLP #AFLP
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... infiltrates maternal hepatocytes ... → Liver dysfunction ... iMedEducation #AFLP
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Injury: • Hepatic ... Venoocclusive disease • Hepatic ... • AST/ALT > ALP ... disease - If ALP ... hemolysis) • ALP
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Identify Acute Liver ... - Specific to liver ... - Assists in liver ... replaced by non-hepatic
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... - Increased ALP ... disturbance (obstructed liver ... Highest • Bone • Liver ... elevation DDX of Hepatic
Hepatic Portal Venous System Drainage Anatomy 1) Most of the blood from abdominal organs goes into the
Hepatic Portal Venous ... goes into the hepatic ... is delivered to hepatocytes ... capillaries of hepatic ... IVC using the hepatic
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... (ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
and Acute Fatty Liver ... of Pregnancy (AFLP ... Hemolysis, Elevated Liver ... exchange 3) Fatty liver ... TTPHUS #HELLP #AFLP
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... ALP - Biliary ... Transaminase, ALP ... SinaiBmoreIMRes #Liver
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