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diagnosis clinical hepatology radiology differential algorithm lfts ct photo obstetrics pathophysiology pregnancy cirrhosis comparison hellp hematology nafld pathology transaminitis abnormal
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... infiltrates maternal hepatocytes ... → Liver dysfunction ... iMedEducation #AFLP
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... features of NASH in liver-biopsy ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... HCC #Prevalence #NEJM
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... (ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
and Acute Fatty Liver ... of Pregnancy (AFLP ... Hemolysis, Elevated Liver ... exchange 3) Fatty liver ... TTPHUS #HELLP #AFLP
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Identify Acute Liver ... Less specific to liver ... - Specific to liver ... - Assists in liver
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... ALP - Biliary ... Transaminase, ALP ... SinaiBmoreIMRes #Liver
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• AST/ALT > ALP ... GGT/5-NT: ↑ - ALP ... disease - If ALP ... both are normal, ALP ... hemolysis) • ALP
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Hemolysis, Elevated Liver ... of Pregnancy (AFLP ... clinical features: Liver ... diagnosis #icp #HELLP #AFLP
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